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Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping

The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is commonly known as amorphous solid dispersion (ASD). API crystallization and/or amorphous phase separation can be detrimental to the bioavailabili...

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Principais autores: Adrian Krummnow, Andreas Danzer, Kristin Voges, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-05-01
Serier:Pharmaceutics
Fag:
phase behavior
miscibility gap
amorphous phase separation
kinetics
Raman imaging
confocal Raman spectroscopy
Online adgang:https://www.mdpi.com/1999-4923/15/5/1395
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