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Phosphorylation of NF-κBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target

Abstract Background Nuclear factor­κB (NF-κB) plays a vital role in hepatocellular carcinoma (HCC). β-arrestin1 (ARRB1) has been proved to enhance the activity of NF-κBp65, and our previous study indicated that ARRB1 promotes hepatocellular carcinogenesis and development of HCC. However, it remains...

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Principais autores: Xuan Xu, Yiming Lei, Lingjun Chen, Haoxiong Zhou, Huiling Liu, Jie Jiang, Yidong Yang, Bin Wu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2021-08-01
Series:Journal of Experimental & Clinical Cancer Research
Assuntos:
Hepatocellular carcinoma
Inflammation
NF-κBp65
Phosphorylation
β-arrestin1
Acceso en liña:https://doi.org/10.1186/s13046-021-02062-x
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