Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear. Here, we further established the role of aerobic glycolysis in murine rod and cone PRs. We show that loss of hexokinase-2 (HK...

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Hauptverfasser:	Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2018-05-01
Schriftenreihe:	Cell Reports
Schlagworte:	hexokinase-2 aerobic glycolysis oxidative phosphorylation rods cones rod metabolism metabolic coupling retinitis pigmentosa
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124718307113
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