Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy

Background Bicuspid aortic valves (BAVs) predispose to ascending aortic aneurysm. Turbulent blood flow and genetic factors have been proposed as underlying mechanisms. Endothelial nitric oxide synthase (eNOS) has been implicated in BAV aortopathy, and its expression is regulated by wall shear stress...

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Bibliografiska uppgifter

Huvudupphov:	Simon Gauer, Brittany Balint, Catherine Kollmann, Jan M. Federspiel, Dominic Henn, Doris Bandner‐Risch, Wolfram Schmied, Hans‐Joachim Schäfers
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Wiley 2020-09-01
Serie:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Ämnen:	aortic valve ascending aortic aneurysm bicuspid aortic valve endothelial nitric oxide synthase hemodynamics
Länkar:	https://www.ahajournals.org/doi/10.1161/JAHA.120.016471
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