Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy

Background Bicuspid aortic valves (BAVs) predispose to ascending aortic aneurysm. Turbulent blood flow and genetic factors have been proposed as underlying mechanisms. Endothelial nitric oxide synthase (eNOS) has been implicated in BAV aortopathy, and its expression is regulated by wall shear stress...

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Hlavní autoři:	Simon Gauer, Brittany Balint, Catherine Kollmann, Jan M. Federspiel, Dominic Henn, Doris Bandner‐Risch, Wolfram Schmied, Hans‐Joachim Schäfers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2020-09-01
Edice:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Témata:	aortic valve ascending aortic aneurysm bicuspid aortic valve endothelial nitric oxide synthase hemodynamics
On-line přístup:	https://www.ahajournals.org/doi/10.1161/JAHA.120.016471
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