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Liver sinusoidal endothelial cells constitute a major route for hemoglobin clearance

Abstract Mild rupture of aged erythrocytes occurs in the spleen, resulting in hemoglobin (Hb) release, whereas pathological hemolysis characterizes several diseases. Hb detoxification is attributed to macrophages, but other routes of Hb clearance remain elusive. Here, we uncover that Hb uptake is ch...

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Hlavní autoři: Gabriela Zurawska, Zuzanna Sas, Aneta Jończy, Raghunandan Mahadeva, Patryk Slusarczyk, Marta Chwałek, Daniel Seehofer, Georg Damm, Rafał Mazgaj, Marcin Skórzyński, Maria Kulecka, Izabela Rumieńczyk, Morgane Moulin, Kamil Jastrzębski, Kevin Waldron, Michal Mikula, Anders Etzerodt, Remigiusz Serwa, Marta Miączyńska, Tomasz P Rygiel, Katarzyna Mleczko-Sanecka
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Nature 2026-01-01
Edice:EMBO Reports
Témata:
Hemoglobin
Hemolytic Disease
LSEC
Macropinocytosis
RBC
On-line přístup:https://doi.org/10.1038/s44319-025-00673-5
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