An in-frame deletion mutation in MLH1 drives Lynch syndrome-associated colorectal cancer

Abstract Lynch syndrome (LS) is the most common inherited disorder predisposing individuals to colorectal cancer (CRC). It results from germline defects in DNA mismatch repair (MMR) genes, which are critical for maintaining genomic integrity. Here, we demonstrate that the expression of the MMR genes...

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Principais autores:	Xiaojuan Lin, Ce Bian, Dongni Liang, Lin Li, Qingqing Tang, Qingli Li
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-07-01
Serija:	BMC Cancer
Teme:	In-frame deletion mutation MLH1 Lynch syndrome Colorectal cancer
Online dostop:	https://doi.org/10.1186/s12885-025-14554-6
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