Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington’s disease (HD), we study vesicl...

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Bibliografske podrobnosti

Principais autores:	Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2021-04-01
Serija:	Cell Reports
Teme:	huntingtin Huntington’s disease axonal transport arginine methylation PRMT6 protein post-translational modification
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2211124721002941
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