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Detection of IDH mutation in glioma by desorption electrospray ionization (DESI) tandem mass spectrometry

Abstract Desorption electrospray ionization (DESI) tandem mass spectrometry (MS) is used to assess mutation status of isocitrate dehydrogenase (IDH) in human gliomas. Due to the diffuse nature of gliomas, total gross resection is not normally achieved during surgery, leading to tumor recurrence. The...

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Principais autores: Mahdiyeh Shahi, Steven Pringle, Michael Morris, Diogo Moniz Garcia, Alfredo Quiñones-Hinojosa, R. Graham Cooks
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2024-11-01
סדרה:Scientific Reports
נושאים:
Multiple reaction monitoring (MRM)
2-hydroxyglutarate
Oncometabolite
Molecular diagnostics
Brain cancer
Ambient ionization
גישה מקוונת:https://doi.org/10.1038/s41598-024-77044-y
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