NMR detects clustering and ultra-weak excipient interactions governing monoclonal antibody viscosity in formulation-relevant conditions

High-concentration formulations of monoclonal antibodies (mAbs) are required for subcutaneous administration but are frequently challenging to develop due to elevated viscosity and colloidal instability. These properties are governed by mAb–mAb interactions that are regulated by additional mAb–excip...

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Egile Nagusiak:	Liza Boëffard-Dosierre, Camille Dagallier, Géraldine Eudier, Vasco Filipe, Atifa Badar-Majeed, Solène Fraumont, Sophie Zinn-Justin, Francois-Xavier Theillet
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis Group 2026-12-01
Saila:	mAbs
Gaiak:	Excipients formulation development monoclonal antibodies NMR spectroscopy protein–excipient interactions viscosity
Sarrera elektronikoa:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2685366
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