NMR detects clustering and ultra-weak excipient interactions governing monoclonal antibody viscosity in formulation-relevant conditions

High-concentration formulations of monoclonal antibodies (mAbs) are required for subcutaneous administration but are frequently challenging to develop due to elevated viscosity and colloidal instability. These properties are governed by mAb–mAb interactions that are regulated by additional mAb–excip...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Liza Boëffard-Dosierre, Camille Dagallier, Géraldine Eudier, Vasco Filipe, Atifa Badar-Majeed, Solène Fraumont, Sophie Zinn-Justin, Francois-Xavier Theillet
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Taylor & Francis Group 2026-12-01
סדרה:	mAbs
נושאים:	Excipients formulation development monoclonal antibodies NMR spectroscopy protein–excipient interactions viscosity
גישה מקוונת:	https://www.tandfonline.com/doi/10.1080/19420862.2026.2685366
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!