क्यूआर कोड

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this study, we combine high...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Ralitsa R. Madsen, James Longden, Rachel G. Knox, Xavier Robin, Franziska Völlmy, Kenneth G. Macleod, Larissa S. Moniz, Neil O. Carragher, Rune Linding, Bart Vanhaesebroeck, Robert K. Semple
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Company of Biologists 2021-03-01
श्रृंखला:Disease Models & Mechanisms
विषय:
pi3k
pik3ca
stemness
pluripotent stem cells
ऑनलाइन पहुंच:http://dmm.biologists.org/content/14/3/dmm048298
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