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Engineered crRNA Drives RPA‐T7‐CRISPR/Cas14a Cascade for Ultrasensitive Detection of ctDNA PIK3CA H1047R

Abstract The early detection of circulating tumor DNA (ctDNA) at mutant allele frequencies below 0.1% remains a critical challenge, significantly impeding therapeutic decision‐making. To address this limitation, TIDE‐Cas14a—an innovative CRISPR/Cas14a‐based duplex detection system is developed that...

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Kaydedildi:
Asıl Yazarlar: Yuanyuan Yu, Mengru Jin, Weiguang Yuan, Yajie Gong, Siwei Li, Xuquan Qin, Jianxun Hou, Jialin Liu, Siyu Liu, Hui Li, Yijun Chu, Yingjie Wang, Youxue Zhang, Fang Fang, Wenhui Hao, Yuling Gu, Qinchen Fan, Jing Lin, Da Pang, Xianyu Zhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2025-11-01
Seri Bilgileri:Advanced Science
Konular:
CRISPR/Cas14a
ctDNA detection
diagnostics
PIK3CA H1047R
RPA
Online Erişim:https://doi.org/10.1002/advs.202507126
Etiketler: Etiketle
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