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Comparison of the Blood–Brain Barrier Transport and Vulnerability to P-Glycoprotein-Mediated Drug–Drug Interaction of Domperidone versus Metoclopramide Assessed Using In Vitro Assay and PET Imaging

Domperidone and metoclopramide are widely prescribed antiemetic drugs with distinct neurological side effects. The impact of P-glycoprotein (P-gp)-mediated efflux at the blood–brain barrier (BBB) on brain exposure and BBB permeation was compared in vitro and in vivo using positron emission tomograph...

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Principais autores: Louise Breuil, Sébastien Goutal, Solène Marie, Antonio Del Vecchio, Davide Audisio, Amélie Soyer, Maud Goislard, Wadad Saba, Nicolas Tournier, Fabien Caillé
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-08-01
coleção:Pharmaceutics
Assuntos:
ATP-binding cassette
drug–drug interaction
membrane transporter
neuropharmacology
pharmacokinetics
PET imaging
Acesso em linha:https://www.mdpi.com/1999-4923/14/8/1658
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