Pharmacokinetic Imaging Using ^99mTc-Mebrofenin to Untangle the Pattern of Hepatocyte Transporter Disruptions Induced by Endotoxemia in Rats

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which control the hepatobiliary elimination of drugs and bile acids. ^99mTc-mebrofenin is a non-metabolized substrate of transporters expressed at the different poles of hepatocytes. ^99mTc-mebro...

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Bibliografische Detailangaben

Hauptverfasser:	Solène Marie, Irene Hernández-Lozano, Marc Le Vée, Louise Breuil, Wadad Saba, Maud Goislard, Sébastien Goutal, Charles Truillet, Oliver Langer, Olivier Fardel, Nicolas Tournier
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-03-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	ABC-transporter drug-induced liver injury hepatotoxicity organic anion-transporting polypeptide pharmacokinetics liver function
Online-Zugang:	https://www.mdpi.com/1424-8247/15/4/392
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