Sustained Baclofen-Induced Activation of GABAB Receptors After Cerebral Ischemia Restores Receptor Expression and Function and Limits Progressing Loss of Neurons

One important function of GABAB receptors is the control of neuronal activity to prevent overexcitation and thereby excitotoxic death, which is a hallmark of cerebral ischemia. Consequently, sustained activation of GABAB receptors with the selective agonist baclofen provides neuroprotection in in vi...

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Автори:	Mohammad Hleihil, Markus Vaas, Musadiq A. Bhat, Karthik Balakrishnan, Dietmar Benke
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2021-09-01
Серія:	Frontiers in Molecular Neuroscience
Предмети:	GABAB receptor cerebral ischemia MCAO OGD baclofen neuroprotection
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fnmol.2021.726133/full
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