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Attenuated titin protein expression is associated with advanced stages of ovarian cancer

This study explores the role of titin, a giant muscle protein, in the progression of epithelial ovarian cancer (EOC). We examined titin levels in tissues and sera from EOC patients across stages I–IV and in chemoresistant EOC cells. Tissue samples underwent immunohistochemistry, and serum titin leve...

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Principais autores: Harvey Sharma, Jaskaran Aujla, Asad Nawaz, Thabet Khasawneh, Ayesha Alvero, Robert T. Morris, Asma Basha, Laila Tutunji, Toshima Z. Parris, Khalil Helou, Ghassan M. Saed
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-03-01
Serier:Molecular Therapy: Oncology
Fag:
MT: Regular Issue
attenuated titin expression
chemoresistance
ovarian cancer
therapeutic marker
titin mutations
Online adgang:http://www.sciencedirect.com/science/article/pii/S2950329925000013
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