Portrayed the development of activated T cell to exhausted T cell based on the ratio of CD28 to CTLA4
Abstract T cell exhaustion, to some extent, limits the clearance of viruses and tumor cells and accounts for the poor effectiveness of immune therapy. The generally accepted classification of exhausted T cells assigns them as progenitor and terminal statuses. However, the outcome of immune therapy b...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer
2026-01-01
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| coleção: | Cancer Immunology, Immunotherapy |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1007/s00262-025-04297-5 |
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