Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis

Abstract Emerging evidence has shown that microbiota dysbiosis and aberrant bile acid (BA) profiles are correlated with disease progression. This study elucidates dysregulated BA metabolism in psoriasis patients and imiquimod-treated female mice, coupled with increased expression of the farnesoid X...

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Autors principals:	Panpan Lian, Renwei Lu, Chaode Gu, Junaid Wazir, Wentong Wang, Yangyongyi Zong, Yun Xia, Jie Ni, Huimei Chen, Enrico Petretto, Eckardt Treuter, Rongrong Fan, Airong Yang, Zhonglan Su, Hongwei Wang, Zhiqiang Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-72417-5
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