Timed secreted proteomes reveal regulation of hepatokines by the liver circadian clock

Abstract Here, we use an ex vivo approach compatible with the circadian timescale to interrogate protein secretion from liver, revealing several findings. Proteomic analyses in male and female mice identify hundreds of proteins that exhibit time-of-day-dependent or clock-dependent secretion involved...

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Autors principals:	Christopher Litwin, Qing Zhang, Ioannis Tsialtas, Zhihong Li, Sophia Hernandez, Steffi Prem, Kristi Dietert, Mallory Keating, Tomoki Sato, Jiyoon Ryu, Lily Q. Dong, Kevin F. Bieniek, Kevin B. Koronowski
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-06-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-73840-4
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