Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress

Abstract Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NADPH, its dynamics, and NADPH/NADP+ ratio. Here, we...

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Detalhes bibliográficos

Principais autores:	Sun Jin Moon, Wentao Dong, Gregory N. Stephanopoulos, Hadley D. Sikes
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2020-09-01
coleção:	Bioengineering & Translational Medicine
Assuntos:	hydrogen peroxide mitochondria NADPH NADPH metabolism NADPH sensor oxidative stress
Acesso em linha:	https://doi.org/10.1002/btm2.10184
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