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CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway

Objective: CLT-003 is a novel phenylphthalimide derivative encapsulated in poly (lactate-glycolic acid) copolymer nanoparticles using nanotechnology techniques. CLT-003 possesses anti-angiogenetic and antitumor activities. Nevertheless, the role and molecular mechanism underlying CLT-003 in pancreat...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Chao Xu, Zekun Li, Yueying Shan, Chunhua She, Yanfang Yang, Tianxing Zhou, Yongjie Xie, Bo Ni, Chenyang Meng, Guangcong Shen, Boyang Fu, Guannan Sheng, Liangliang Wu, Jinlong Pei, Tiansuo Zhao, Song Gao, Hongwei Wang, Chengqi Deng, Kaiyuan Wang, Antao Chang, Chongbiao Huang, Lei Shi, Shengyu Yang, Jun Yu, Jihui Hao, Xiuchao Wang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: China Anti-Cancer Association 2025-12-01
Seri Bilgileri:Cancer Biology & Medicine
Konular:
clt-003
pancreatic ductal adenocarcinoma
hif-1α
pi3k/akt/mtor
malignant progression
Online Erişim:https://www.cancerbiomed.org/content/22/12/1558
Etiketler: Etiketle
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