CLT-003 exerts anti-tumor activity in pancreatic cancer by blocking the PI3K/AKT/HIF-1α pathway

Objective: CLT-003 is a novel phenylphthalimide derivative encapsulated in poly (lactate-glycolic acid) copolymer nanoparticles using nanotechnology techniques. CLT-003 possesses anti-angiogenetic and antitumor activities. Nevertheless, the role and molecular mechanism underlying CLT-003 in pancreat...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Chao Xu, Zekun Li, Yueying Shan, Chunhua She, Yanfang Yang, Tianxing Zhou, Yongjie Xie, Bo Ni, Chenyang Meng, Guangcong Shen, Boyang Fu, Guannan Sheng, Liangliang Wu, Jinlong Pei, Tiansuo Zhao, Song Gao, Hongwei Wang, Chengqi Deng, Kaiyuan Wang, Antao Chang, Chongbiao Huang, Lei Shi, Shengyu Yang, Jun Yu, Jihui Hao, Xiuchao Wang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	China Anti-Cancer Association 2025-12-01
Serie:	Cancer Biology & Medicine
Soggetti:	clt-003 pancreatic ductal adenocarcinoma hif-1α pi3k/akt/mtor malignant progression
Accesso online:	https://www.cancerbiomed.org/content/22/12/1558
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!