Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Background The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis. Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia....

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Principais autores:	Iria Vázquez, Miren Maicas, José Cervera, Xabier Agirre, Oskar Marin-Béjar, Nerea Marcotegui, Carmen Vicente, Idoya Lahortiga, Maria Gomez-Benito, Claudia Carranza, Ana Valencia, Salut Brunet, Eva Lumbreras, Felipe Prosper, María T. Gómez-Casares, Jesús M. Hernández-Rivas, María J. Calasanz, Miguel A. Sanz, Jorge Sierra, María D. Odero
Format:	Artigo
Jezik:	Inglês
Izdano:	Ferrata Storti Foundation 2011-10-01
Serija:	Haematologica
Online dostop:	https://haematologica.org/article/view/6091
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