TLR2 or TLR4 Stimulation Induces Transmembrane TNF-Driven Priming in Macrophages Which Results in Improved Clearance of a Subsequent <italic>Staphylococcus aureus</italic> Infection

<p>Introduction: Toll-like receptor (TLR) engagement on macrophages can improve responsiveness to infection. TNF is upregulated following TLR2 or TLR4 stimulation. We sought to determine whether and how the two bioactive forms of TNF, soluble (sTNF) and transmembrane (tmTNF), may be contr...

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Autors principals:	Abby M. Luu, Alexis A. Hatton, Jasper Gattiker, Kelly M. Shepardson, Monica N. Hall, Evelyn Benson, Diane Bimczok, Agnieszka Rynda-Apple
Format:	Artigo
Idioma:	Inglês
Publicat:	Karger Publishers 2025-01-01
Col·lecció:	Journal of Innate Immunity
Accés en línia:	https://karger.com/article/doi/10.1159/000546011
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