CD206+ tumor-associated macrophages cross-present tumor antigen and drive antitumor immunity

In many solid cancers, tumor-associated macrophages (TAM) represent the predominant myeloid cell population. Antigen (Ag) cross-presentation leading to tumor Ag–directed cytotoxic CD8+ T cell responses is crucial for antitumor immunity. However, the role of recruited monocyte-derived macrophages, in...

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Detalhes bibliográficos

Principais autores:	Madhura Modak, Ann-Kathrin Mattes, Daniela Reiss, Wioletta Skronska-Wasek, Rebecca Langlois, Nicolas Sabarth, Renate Konopitzky, Fidel Ramirez, Katharina Lehr, Tobias Mayr, David Kind, Coralie Viollet, Lee Kim Swee, Jutta Petschenka, Karim C. El Kasmi, Elfriede Noessner, Kerstin Kitt, Stefan Pflanz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2022-06-01
coleção:	JCI Insight
Assuntos:	Immunology Oncology
Acesso em linha:	https://doi.org/10.1172/jci.insight.155022
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