General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants

Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). Though most people with CF have one or two copies of the ΔF508 mutation, there are hundreds of other distinct CF mutations that vary in their mechanistic effects and...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Austin Tedman, John A Olson III, Minsoo Kim, Catherine Foye, JaNise J Jackson, Eli F McDonald, Andrew G McKee, Karen Noguera, Charles P Kuntz, Jens Meiler, Kathryn E Oliver, Lars Plate, Jonathan P Schlebach
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2025-12-01
Colecção:	eLife
Assuntos:	CFTR corrector proteostasis cystic fibrosis membrane protein folding protein misfolding
Acesso em linha:	https://elifesciences.org/articles/107180
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!