Lumacaftor and Matrine: Possible Therapeutic Combination to Counteract the Inflammatory Process in Cystic Fibrosis

Cystic fibrosis is a monogenic, autosomal, recessive disease characterized by an alteration of chloride transport caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene. The loss of Phe residue in position 508 (ΔF508-CFTR) causes an incorrect folding of the protei...

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Hlavní autoři:	Michela Pecoraro, Silvia Franceschelli, Maria Pascale
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2021-03-01
Edice:	Biomolecules
Témata:	Cystic fibrosis (CF) oxidative stress inflammation CFTR rescue Vx-809 (Lumacaftor) Matrine
On-line přístup:	https://www.mdpi.com/2218-273X/11/3/422
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