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BRAFV600E/pTERT double mutated papillary thyroid cancers exhibit immune gene suppression

IntroductionBRAFV600E mutation (BRAFmut) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERTmut) in the presence of BRAFmut (BRAFmutpTERTmut) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic...

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Autores principales: Ana-Maria Sigarteu Chindris, Michael Rivera, Yaohua Ma, Asha Nair, Yi Liu, Xue Wang, Brian M. Necela, Jennifer M. Kachergus, John D. Casler, Christopher Brett, Ana M. Rivas Mejia, Victor J. Bernet, John A. Copland, Keith L. Knutson, E. Aubrey Thompson, Robert C. Smallridge
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2024-12-01
Colección:Frontiers in Endocrinology
Materias:
papillary thyroid cancer (PTC)
BRAF mutation V600 E
TERT promoter mutation (pTERT)
immune genes
lymphocytic infiltration
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fendo.2024.1440722/full
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