PAFAH1B1 governs follicular development by modulating the protein complex of CCNE1-CDK2-CDK1 to induce cell cycle arrest

BackgroundOvarian follicle development plays a crucial role in mammalian fertility, which is primarily regulated by granulosa cell (GC) proliferation and cell cycle. Cell cycle dysregulation collectively might drive follicular atresia through GC dysfunction. However, the underlying molecular mechani...

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Autors principals:	Yingting He, Yinqi Zhou, Ruiqi Wang, Weili Liao, Nian Li, Jiaqi Li, Zewen Sun, Jianguo Zhao, Xiaolong Yuan
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-09-01
Col·lecció:	Frontiers in Cell and Developmental Biology
Matèries:	CCNE1-CDK2-CDK1 complex cell cycle DNA methylation follicular development PAFAH1B1
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1919659/full
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