Bacteriophage-derived endolysins restore antibiotic susceptibility in β-lactam- and macrolide-resistant Streptococcus pneumoniae infections

Abstract Streptococcus pneumoniae, the pneumococcus, is a cause of major illness globally. Invasive pneumococcal disease (IPD) is characterized by pneumococci invading blood (bacteremia), lungs (pneumonia), or brain and cerebrospinal fluid (meningitis). Meningitis remains an important global health...

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Autori principali:	Niels Vander Elst, Kristine Farmen, Lisa Knörr, Lotte Merlijn, Federico Iovino
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-05-01
Serie:	Molecular Medicine
Soggetti:	Streptococcus pneumoniae Invasive Pneumococcal Disease Meningitis Antibiotic-resistance Endolysins Penicillin
Accesso online:	https://doi.org/10.1186/s10020-025-01226-1
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