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A bacteriophage endolysin that eliminates intracellular streptococci

PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections. We show that the PlyC holoenzyme, mediated by its PlyCB subunit, crosses epithelial c...

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Principais autores: Yang Shen, Marilia Barros, Tarek Vennemann, D Travis Gallagher, Yizhou Yin, Sara B Linden, Ryan D Heselpoth, Dennis J Spencer, David M Donovan, John Moult, Vincent A Fischetti, Frank Heinrich, Mathias Lösche, Daniel C Nelson
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2016-03-01
coleção:eLife
Assuntos:
bacteriophage
membrane protein
endolysin
structure/function
Acesso em linha:https://elifesciences.org/articles/13152
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