Arginine 123 of apolipoprotein A-I is essential for lecithin:cholesterol acyltransferase activity

ApoA-I activates LCAT that converts lipoprotein cholesterol to cholesteryl ester (CE). Molecular dynamic simulations suggested earlier that helices 5 of two antiparallel apoA-I molecules on discoidal HDL form an amphipathic tunnel for migration of acyl chains and unesterified cholesterol to the acti...

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Autores principales:	Irina N. Gorshkova, Xiaohu Mei, David Atkinson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2018-02-01
Colección:	Journal of Lipid Research
Materias:	cholesterol/metabolism fatty acid/transferase high density lipoprotein/metabolism high density lipoprotein/structure lipid and lipoprotein metabolism catalytic efficiency
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0022227520342371
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