EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease

Abstract Background Diabetic kidney disease (DKD) is characterized by progressive fibrosis, oxidative stress, and mitochondrial dysfunction, contributing to renal dysfunction. EphrinB2, a cell surface protein, has been implicated in tissue repair and fibrosis, but its role in DKD remains poorly unde...

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Detalhes bibliográficos

Principais autores:	Lihua Ni, Qiuyuan Zhou, Xueyun Gao, Feng Chen, Ayinigaer Yusufu, Jin-Hu Chen, Cheng Yuan, Xiaoyan Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-07-01
coleção:	Journal of Translational Medicine
Assuntos:	Diabetic kidney disease (DKD) EphrinB2 Renal fibrosis Mitochondrial dynamics Oxidative stress Epac1-Rap1 signaling
Acesso em linha:	https://doi.org/10.1186/s12967-025-06852-1
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