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DWN12088, A Prolyl-tRNA Synthetase Inhibitor, Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis

Background Nonalcoholic steatohepatitis (NASH) is a liver disease caused by obesity that leads to hepatic lipoapoptosis, resulting in fibrosis and cirrhosis. However, the mechanism underlying NASH is largely unknown, and there is currently no effective therapeutic agent against it. DWN12088, an agen...

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Principais autores: Dong-Keon Lee, Su Ho Jo, Eun Soo Lee, Kyung Bong Ha, Na Won Park, Deok-Hoon Kong, Sang-In Park, Joon Seok Park, Choon Hee Chung
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Diabetes Association 2024-01-01
coleção:Diabetes & Metabolism Journal
Assuntos:
idiopathic pulmonary fibrosis
inflammation
non-alcoholic fatty liver disease
palmitic acid
prolyl trna synthetase
transforming growth factor beta
Acesso em linha:http://e-dmj.org/upload/pdf/dmj-2022-0367.pdf
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