Scaling the manufacture of adipose tissue-derived mesenchymal stromal cells: integrated bioreactor workflows from inoculation to harvest without the need of seed train

Abstract Background The production of human mesenchymal stromal cells (hMSC) for therapeutic use requires scalable, efficient and standardized manufacturing processes that could further benefit from shortening manufacturing time, automate and simplify operations with closed systems. This study aimed...

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मुख्य लेखकों:	Marta H. G. Costa, Ana Paula Terrasso, Inês E. Crespo, Raúl Valero, Beatriz Menéndez, Beatriz Painho, Carolina D. Sousa, Beatriz Gamelas, Hélio Tomás, Pablo Mancheno-Corvo, Ramón Menta, Carmen R. Gugel, Vanessa Fernández-Gómez, Ángel Herrero-Méndez, Irene Zamora Mármol, Alvaro Avivar-Valderas, Laura M. Pérez, Olga de la Rosa, Eleuterio Lombardo, Margarida Serra, Maitane Ortiz-Virumbrales
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	BMC 2026-01-01
श्रृंखला:	BMC Biotechnology
विषय:	Mesenchymal stromal cells Bioreactors No seed train Microcarriers Closed bioprocess Xeno-free medium
ऑनलाइन पहुंच:	https://doi.org/10.1186/s12896-026-01101-9
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