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Subcellular Localization of Beta Catenin in Colorectal Non Neoplastic and Neoplastic Lesions

Loss of adenomatous polyposis coli (APC) function is typically an early event in sporadic colorectal cancer (CRC) pathogenesis. The key tumor suppressor function of the APC protein lies in its ability to destabilize free cytoplasmic beta catenin. This lead to the accumulation of nuclear beta caten...

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Autori principali: Diah Rini Handjari, Pamela Abineno, Budiningsih Siregar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Universitas Indonesia 2012-01-01
Serie:Makara Journal of Health Research
Soggetti:
beta catenin
colorectal cancer
colorectal adenoma
chronic colitis
Accesso online:http://journal.ui.ac.id/index.php/health/article/view/942
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