H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI vari...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Mable Chan, Anders Leung, Tamiko Hisanaga, Brad Pickering, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor, Gary Wong, Yuhai Bi, Shawn Babiuk, Yohannes Berhane, Darwyn Kobasa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-01-01
Schriftenreihe:	Viruses
Schlagworte:	hpai h7n9 influenza virus mammalian adaptation mice polybasic ha
Online-Zugang:	https://www.mdpi.com/1999-4915/12/1/65
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