Efficient targeted recombination with CRISPR/Cas9 in hybrids of Caenorhabditis nematodes with suppressed recombination

Abstract Background Homology-based recombination (HR) is the cornerstone of genetic mapping. However, a lack of sufficient sequence homology or the presence of a genomic rearrangement prevents HR through crossing, which inhibits genetic mapping in relevant genomic regions. This is particularly true...

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Detalhes bibliográficos

Principais autores:	Dongying Xie, Bida Gu, Yiqing Liu, Pohao Ye, Yiming Ma, Tongshu Wen, Xiaoyuan Song, Zhongying Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	BMC Biology
Assuntos:	Targeted recombination CRISPR/Cas9 C. briggsae C. nigoni Hybrid Genetic mapping
Acesso em linha:	https://doi.org/10.1186/s12915-023-01704-0
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