A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations

Messenger RNA (mRNA) therapeutics show considerable promise but face delivery challenges, as effective cytosolic entry and subsequent translation are normally limited by endosomal entrapment. While various approaches have been used to investigate determinants of effective RNA delivery, these methods...

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Главные авторы:	Alfredo D. Smart, Merryn E. Hughes, Angela Downie Ruiz Velasco, Naoto Hori, Snow Stolnik, Catherine L. Jopling
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-09-01
Серии:	Molecular Therapy: Nucleic Acids
Предметы:	MT: Delivery Strategies mRNA delivery endoplasmic reticulum signal peptide proximity biotinylation APEX
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2162253125001568
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