Insulin production in the retina drives autocrine signalling and metabolism reprogramming of the ARPE-19, a retinal pigment epithelium cellular model

Abstract The retinal pigment epithelium (RPE) plays a pivotal role in retinal homeostasis and energy metabolism. A recent study demonstrates that RPE cells release insulin in response to photoreceptor outer segment (POS) phagocytosis and starvation conditions. However, the downstream signalling path...

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Detalhes bibliográficos

Principais autores:	Alessandra Puddu, Matilde Balbi, Silvia Ravera, Isabella Panfoli, Davide Maggi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer 2026-05-01
coleção:	Cellular and Molecular Life Sciences
Assuntos:	Retinal pigment epithelium Phagocytosis of photoreceptor outer segment Retinal metabolism Local insulin production AKT signalling
Acesso em linha:	https://doi.org/10.1007/s00018-026-06222-0
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