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Development of an immunodeficient mouse that allows for conditional ablation of monocytic cells

Background and aimsImmunodeficient mice, like the NOD-SCID-Gamma (NSG) strain, are important for the study of xenogeneic cells because of their lack of lymphocytes, dysfunctional hemolytic complement factor 5 (C5), and macrophage defects making them permissive hosts. Nonetheless, cellular barriers r...

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Principais autores: Alvin J. Hui, Kelly Lai, Eva H. Doyle, Guadalupe Rivera-Torruco, Alan G. Gutierrez, Emily J. Du, Yarah B. M. Meijer, Gabrielle Smith, Renata Gilfanova, Kenton G. Chung, Kirsten M. Auclair, Pamela Milani, Rachael P. Jackman, Johnson Q. Tran, Marcus O. Muench
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-11-01
Serier:Frontiers in Immunology
Fag:
macrophage - cell
phagocyte
hemolytic complement
cell chimeras
humanized mice
xenotransplantation
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699385/full
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