Development of an immunodeficient mouse that allows for conditional ablation of monocytic cells

Background and aimsImmunodeficient mice, like the NOD-SCID-Gamma (NSG) strain, are important for the study of xenogeneic cells because of their lack of lymphocytes, dysfunctional hemolytic complement factor 5 (C5), and macrophage defects making them permissive hosts. Nonetheless, cellular barriers r...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Alvin J. Hui, Kelly Lai, Eva H. Doyle, Guadalupe Rivera-Torruco, Alan G. Gutierrez, Emily J. Du, Yarah B. M. Meijer, Gabrielle Smith, Renata Gilfanova, Kenton G. Chung, Kirsten M. Auclair, Pamela Milani, Rachael P. Jackman, Johnson Q. Tran, Marcus O. Muench
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2025-11-01
סדרה:	Frontiers in Immunology
נושאים:	macrophage - cell phagocyte hemolytic complement cell chimeras humanized mice xenotransplantation
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1699385/full
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!