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Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation

Abstract Increased global protein synthesis is associated with the development and progression of several aging-related diseases and disorders. Strategies like calorie restriction and pharmacological inhibition of protein synthesis have exhibited health-promoting effects. However, the complex molecu...

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Furkejuvvon:
Váldodahkkit: Amarjeet Shrama, Yanlin Zi, Anwit Shriniwas Pandit, Kirtika Jha, Vikrant Kumar Sinha, Dimple Nagesh, Bhoomika Shivanaiah, Venkatraman Ravi, Souvik Ghosh, Danish Khan, Arathi Bangalore Prabhashankar, Thoniparambil Sunil Sumi, Satish Rajpurohit, Sunayana Ningaraju, Sukanya Raghu, Anand Srivastava, Mahavir Singh, Hening Lin, Nagalingam R Sundaresan
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Springer Nature 2026-03-01
Ráidu:EMBO Reports
Fáttát:
SIRT2
Protein Synthesis
Rheb
Ubiquitination
Cardiac Hypertrophy
Liŋkkat:https://doi.org/10.1038/s44319-026-00724-5
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