Target inhibition of SPAK in choroid plexus attenuates T cell infiltration and demyelination in experimental autoimmune encephalomyelitis

Abstract Background Disease-modifying therapies (DMTs) that prevent immune cell infiltration into the brain have demonstrated efficacy in multiple sclerosis (MS) treatment. However, their unpredictable adverse effects necessitate the development of safer therapeutic alternatives. The choroid plexus...

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Hlavní autoři:	Chenxing Qi, Yeping Wang, Xuhang Li, Cheng Zheng, Yi Gu, Junxiao Hu, Yiming Qiu, Guomin Xie, Shujun Xu, Yuyin Zheng, Zhongyue Lv, Wu Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-03-01
Edice:	Journal of Neuroinflammation
Témata:	Choroid plexus SPAK Tight junctions Multiple sclerosis Experimental autoimmune encephalomyelitis
On-line přístup:	https://doi.org/10.1186/s12974-025-03407-5
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