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Target inhibition of SPAK in choroid plexus attenuates T cell infiltration and demyelination in experimental autoimmune encephalomyelitis

Abstract Background Disease-modifying therapies (DMTs) that prevent immune cell infiltration into the brain have demonstrated efficacy in multiple sclerosis (MS) treatment. However, their unpredictable adverse effects necessitate the development of safer therapeutic alternatives. The choroid plexus...

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Principais autores: Chenxing Qi, Yeping Wang, Xuhang Li, Cheng Zheng, Yi Gu, Junxiao Hu, Yiming Qiu, Guomin Xie, Shujun Xu, Yuyin Zheng, Zhongyue Lv, Wu Zheng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-03-01
Serier:Journal of Neuroinflammation
Fag:
Choroid plexus
SPAK
Tight junctions
Multiple sclerosis
Experimental autoimmune encephalomyelitis
Online adgang:https://doi.org/10.1186/s12974-025-03407-5
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