Rotavirus NSP1 Subverts the Antiviral Oligoadenylate Synthetase-RNase L Pathway by Inducing RNase L Degradation

ABSTRACT The interferon (IFN)-inducible 2′,5′-oligoadenylate synthetase (OAS)-RNase L pathway plays a critical role in antiviral immunity. Group A rotaviruses, including the simian SA11 strain, inhibit this pathway through two activities: an E3-ligase related activity of NSP1 that degrades proteins...

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Detalhes bibliográficos

Principais autores:	Jin Dai, Guanghui Yi, Asha A. Philip, John T. Patton
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2022-12-01
coleção:	mBio
Assuntos:	rotavirus interferon OAS-RNase L nonstructural protein 1 phosphodiesterase OAS
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.02995-22
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