Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence
ABSTRACT Endoribonuclease non-structural protein 15 (nsp15) (EndoU) is conserved among coronaviruses (CoVs) and is crucial for viral replication, evasion of the innate immune system, and virulence. EndoU-deficient CoVs can activate the interferon (IFN) response and attenuate their virulence, and nsp...
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| Автори: | , , , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
American Society for Microbiology
2023-12-01
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| Серія: | Microbiology Spectrum |
| Предмети: | |
| Онлайн доступ: | https://journals.asm.org/doi/10.1128/spectrum.02209-23 |
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