Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine

Placental malaria is a public health burden particularly in Africa as it causes severe symptoms and results in stillbirths or maternal deaths. Plasmodium falciparum protein VAR2CSA drives placental malaria (PM) in pregnant women by adhering to chondroitin sulfate A (CSA) on the placenta. VAR2CSA is...

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Hlavní autoři:	Jasmita Gill, Soumyananda Chakraborti, Praveen Bharti, Amit Sharma
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-11-01
Edice:	International Journal of Infectious Diseases
Témata:	Placental malaria VAR2CSA Placental malaria vaccine Field isolates, Structural mapping
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S1201971221006871
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