Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae

Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear. Here, by utilizing whole genome sequencing, we report a plasmid-mediated tigecycline resistance mechanism, a 6,489 bp Resistance-no...

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Päätekijät:	Shijun Sun, Hua Gao, Yudong Liu, Longyang Jin, Ruobing Wang, Xiaojuan Wang, Qi Wang, Yuyao Yin, Yawei Zhang, Hui Wang
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Taylor & Francis Group 2020-01-01
Sarja:	Emerging Microbes and Infections
Aiheet:	Plasmid-mediated tigecycline-resistant K. pneumoniae tmexCD1-toprJ1 efflux pump mcr-8·5 tmexCD1-mcr co-harbouring plasmid CRKP
Linkit:	https://www.tandfonline.com/doi/10.1080/22221751.2020.1768805
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